Sciatica is the name given to pain caused by irritation of the sciatic nerve, a long nerve that begins in the lower spine and extends down the back of each leg. The most common cause of sciatica is a bulging or herniated disc in the lower spine, which pushes against the sciatic nerve. Sciatica pain varies from person to person. The location of the pain can be anywhere along the path of the sciatic nerve – ranging from the lower back and buttock, down behind the thigh and into the calf. The pain can feel like a cramp or may be excruciating and can make sitting or standing very difficult. For others, it is a sharp or shooting pain, or a “pins and needles” feeling. Right now, doctors at select centers in the US are conducting a new research study for sciatica sufferers. The study is for an investigational study treatment designed to provide long-term relief of sciatica pain. It involves a single injection that does not contain steroids or opioids. If you’ve been struggling with sciatica leg pain for at least 6 weeks, or have been told you have a bulging disc, this study may be right for you.